Resistem™

Resistem™ is an anti-aging cosmetic active developed by Sederma (part of the Croda group), derived from the stem cell culture of the plant Globularia cordifolia. It acts as a "bodyguard" for the skin, stimulating defense mechanisms similar to hormesis, which help the skin protect and regenerate itself autonomously. Its main benefits include cellular detoxification (maintaining proteasome activity), extending cellular lifespan (stimulating sirtuin-1), and tissue regeneration (preserving skin stem cells). Additionally, Resistem™ helps reduce the levels of pro-aging agents and microinflammation induced by toxins, decreasing redness and enhancing the skin's natural radiance. It is suitable for sensitive skin and can be used in skincare products such as face and neck creams, eye area care, and sun protection.

CAS Number

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INCI name(s)

Globularia Cordifolia Callus Culture Extract, Glycerin