Increase your API content and decrease tablet size with PEARLITOL® 200 GT

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Revolutionize your tablet formulations with PEARLITOL® 200 GT – the latest innovation from Roquette. Engineered to maximize API content, enhance production efficiency and enable smaller tablets without compromising stability

Tablet capping solutions

Tablet manufacturers often face challenges with capping (where the top or bottom layer of a tabletseparates during or after compression) and the need to lower API (Active Pharmaceutical Ingredient) content to maintain tablet integrity. PEARLITOL® 200 GT overcomes these issues with enhanced powder properties that improve compressibility and reduce capping risks. Its high powder density allows for greater drug loading, enabling smaller, more efficient tablets without compromising stability.
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A breakthrough in mannitol excipients

A recent study compared PEARLITOL® 200 GTwith two widely used, directly compressible mannitol grades – Mannitol SD-A (spray-dried) and Mannitol G-B (granulated) – using sitagliptin, an API prone to capping. Simulations on a high-speed rotary press (140,000 tablets per hour) showed that PEARLITOL® 200 GT enables API incorporation of up to 30%, compared to just 20% with conventional mannitol grades. This breakthrough delivers important benefits:
  • High API load: PEARLITOL 200 GT boosts API loading by 50%, optimizing formulation efficiency and maximizing yield per batch
  • Streamlined tablet design: Achieve up to 33% reduction in tablet weight and size, enhancing patient compliance with smaller, lighter and easier to swallow tablets
  • Superior production efficiency: Reduce capping risks and ensure stable, high-speed manufacturing, delivering consistent, high-quality tablets to meet market demands with confidence
We’re committed to developing innovative excipients that empower pharmaceutical manufacturers to optimize formulations, overcome production challenges and enhance patient experience.
Discover how PEARLITOL® 200 GT can transform your formulations. Read the full case study here.
Contact us to find out more, or to get support for your application. We’re here to help!