Enhanced antigen Adsorption and product characteristics
The original Adju-Phos®, a sterilized hydrated aluminum hydroxyphosphate colloid gel, is
a classical product in Biosector’s product portfolio and it has been used as an adjuvant in vaccines for human use by leading international vaccine producers for more than 40 years.
At physiological pH Adju-Phos® is negatively charged and is therefore able to adsorb positively charged protein antigens by electrostatic attraction. To minimize a.o. vaccination discomfort vaccines normally hold pH values at or close to physiological pH.
In recent years there has been a quest to make multivalent vaccines protecting against a larger number of infectious agents and diseases than previously. To meet this quest Biosector has developed a modified Adju-Phos® which we have named Adju-Phos® ZP.
With Adju-Phos® ZP we have modified the surface characteristics to enhance the zeta-potential
of the gel particles. This modification leads to the ability to adsorb more protein antigen. This is generally the case with positively charged protein antigens possessing an alkaline isoelectric point, as exemplified and demonstrated by
e.g. the model protein lysozyme (IEP=11).
We see an attractive potential for Adju-Phos® ZP in the development of new and improved multivalent vaccines. Samples of Adju-Phos® ZP are expected to be made available for testing ultimo 2017.